Couple of things here:

1. You did not mention your orthotics are specific to cycling. (The arch has a different role vs. walking of leg length discrepancy, etc) If they were not cast with a metarsal button, you probably need one.
2. The "openness" of the new shoe may mean that your foot is getting crammed into the toebox and the tingling is metarsal nerve compression.
3. The drape of your foot or varus rotation may be coming into play and canting the shoe may be in order.
4. Last but not least it may be the cleat placement-seat height relationship that could be contributing to the issue.
"Yo Tad!
Thanks for the feedback. I put a thicker wedge under the medial side of the orthotics to address the cant of my foot and the foot numbness is practically gone! That was one variable I hadn't addressed. I think you fixed it yo!"